To get a steady plasma level of choline, it's best to take 2-3 doses per day. University of Oslo researchers found Choline to improve executive function and mental processing. Sport performance coaches can consider adding A-GPC to the diet of speed and power athletes to enhance muscle performance. (Journal of the International Society of Sports Nutrition 12). Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults. All rights reserved. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. Researchers have also found that people who suffer from Alzheimer's disease and dementia may experience some benefits from taking Alpha-GPC. Finding your optimal dosage: Some people have seen better results from exceeding the official recommended dose. Alpha GPC stacks very well with the top supplements for energy. What Are The Benefits Of Alpha-GPC For Cognition? Phoshpolipids are the raw materials we use to repair brain-cell membranes. 1. Alpha-GPC is an effective nootropic supplement that can enhance cognitive function. 600mg of Alpha GPC 45 minutes before training increased athlete power output by 14% as assessed by bench throws. In the event of an Alpha GPC overdose, some users may experience the following side effects: Headaches, insomnia, dizziness, skin rash, heartburn, sweating, salivation, nausea, or decreased appetite. RNA and DNA (deoxyribonucleic acid) are the main information carrying molecules in each of your cells. Numerous clinical studies back Alpha GPC for demonstrating the following health benefits: All the listed Alpha GPC benefits are significant. I thought it was simply a "Go-along" to support the benefits of the racetam I'm already taking (phenylpiracetam). What is the correct Alpha GPC dosage? Low levels of phosphatidylcholine are associated with neurological disorders, including Alzheimers disease,[16] dementia,[17] and schizophrenia.[18], The recommended dosage for alpha GPC, based on studies on its use in alleviating cognitive decline, is 1200 mg daily, divided into three doses of 400 mg.[19], This is also the dosing recommendation for Glilitin, the Russian prescription form of alpha GPC.[20]. Alpha-GPC is thought to help prevent age-related decline in cognitive function by increasing levels of acetylcholine in the brain by acting as a pro-cholinergic nootropic agent (4). It's converted to -GPC through two different pathways: The Kennedy Pathway is the chained-together reactions that make up one of our most important mechanisms for regulating cell growth. Tayebati SK, Di Tullio MA, Tomassoni D, Amenta F. As we mentioned, Alpha GPC is a potent source of choline, and it's been shown to boost cognitive function. mismos00 9 yr. ago I had the exact same experience. Alpha GPC has a shorter half-life versus CDP Choline: Alpha GPC lasts 4-6 hours in the body, whereas CDP Choline lasts 60-70 hours (roughly 3 days). Alpha-GPC is a compound known for improving mental performance and endurance by increasing attention span ( 2 ). Alpha GPC is effective at increasing lower body force production after 6 days of supplementation. Then, space your doses by 8-12 hours. 1. Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimers disease. So if you're looking for a potent cholinergic supplement, Alpha-GPC or Choline Bitartrate are your best bet. [9], A 2021 cohort study of more than 12 million participants (at least 50 years old), including 108,877 alpha-GPC users, reported that alpha-GPC use for at least 12 months was associated with an increased risk of stroke over 10 years. As we age, our bodies produce less and less acetylcholine. Once youve assessed tolerance and effect, you may increase your dose in a stepwise fashion. Whether its a pre-workout supplement, post-workout recovery, or for athletic performance, the dose mentioned above has been proven beneficial. Second, make sure the product you're buying is pure Alpha-GPC. This page was last updated on July 16, 2021. Some people use it to increase the speed of cognition as well. Fast Worldwide Shipping Made in the UK 300+ Verified Reviews All Cards and PayPal Accepted. Alpha-GPC (L-alpha-glycerophosphocholine, choline alfoscerate) is a water-soluble nutrient which serves as a precursor to both choline and glycerophosphate within the brain. Thank you for signing up. All of our bodies break down Choline at different rates, so some people may need more. You'll also discover stacking ideas, alternatives, and understand how much Alpha GPC you need to take for optimal cognitive performance. Each molecule of alpha GPC is made up of about 40% choline, which it delivers directly to the brain.[12], Alpha GPCs ability to cross the blood-brain border makes it a particularly efficient cholinergic, surpassing other cholinergics and even choline itself at increasing circulating levels of choline in the central nervous system.[13]. Daily dosing of 300-1200mg cumulatively has been documented as safe and effective for most users. The half-life of . This speaks to its ability to improve brain health and cognition levels. These products are not intended to diagnose, treat, cure or prevent any disease or health condition. Clinical evaluation of a new synthetic protease inhibitor in open heart surgery. Its high bioavailability allows it to penetrate the blood-brain barrier quickly and efficiently. Work your daily doses in wherever is most . Its half-life is about an hour and it is completely eliminated in the urine within 24 hours. This Framingham study included 1,371 healthy young men and women. So now you're releasing more of the motivation chemical and you're more sensitive to it. Clin Ther 2003;25:178-93. It's thought to work by increasing levels of acetylcholine in the brain, which is a neurotransmitter involved in memory formation and learning (2). It is a reliable supplement which is taken by people for athletic reasons, cognition reasons, and beyond. Alpha-GPC, also known as choline alfoscerate and L-Alpha glycerylphosphorylcholine, is a natural choline compound found in the brain. Alpha GPCs mechanisms of action have been extensively studied and are well understood, though how it affects some neuronal functions remains unclear. Scopolamine blocks this same chemical. An important fact to remember is that Alpha GPC is 40% choline by weight. Should you stack Huperzine A and Alpha-GPC? It is possible that alpha-GPC decreases the effects of scopolamine, but it's not clear if this actually happens. Glycerol-1-phosphate is used to support cellular membranes. Alpha-GPC improves mood and increases mental energy. ", I've been taking Alpha GPC for a few months now, and I can definitely say it's helped my cognitive function. Caffeine: Caffeine is seen to increase Acetylcholine release because it improves our ability to absorb Choline. . It appears to also support cellular membranes, and may help prevent cognitive decline. View abstract. Alpha GPCs ability to increase choline levels makes it an effective cognition enhancer, facilitating the production of the neurotransmitter acetylcholine. There have been numerous studies conducted which speak to the effectiveness of Alpha GPC in achieving the benefits examined above. Alpha Brain works by increasing your levels of acetylcholine which enhances both memory and learning abilities. Alpha GPC is 40% Choline by weight. The way you take Alpha-GPC for cognitive enhancement will depend on your goals. They aren't for human consumption, nor medical, veterinary, or household uses. The recommended dosage for Alpha-GPC will depend on the users goal. Alpha GPC is more bioavailable than other sources of choline for brain benefits. Alpha-GPC is a non-essential nutrient, which means that your body can produce it on its own. Lethargic and depressed. (Boston University - 4). Among the best nootropics on the market, Alpha GPC sits atop the list of powerful choline sources. There are a lot of scams out there, and you don't want to end up with a product that doesn't live up to its claims. Finding your optimal dosage: Some people have seen better results from exceeding the "official" recommended dose. The results of the trial suggested that Alpha GPC produced a definite symptomatic improvement. The focus of this article is on helping you decide whether Alpha-GPC is a substance that you should consider adding to your diet, or to your existing supplement routine. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. WebMD does not provide medical advice, diagnosis or treatment. Alpha-GPC is a biosynthetic precursor of acetylcholine (ACh) and one of the most bioavailable forms of choline. A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citocholine in normal volunteers. In a study involving 32 healthy young volunteers, alpha GPC effectively restored memory following temporary chemically-induced amnesia.[4], Anecdotal experience reports affirm that alpha GPC is an effective nootropic that provides a powerful cognitive boost, along with increased energy and motivation.[5][6][7]. [27] [28] Choline has been widely studied to be integral to our cognition and overall brain development. Overall, we believe that the pros outweigh the cons and that Alpha-GPC is an effective nootropic supplement. If you are still in doubt, the option is always available to consult a physician or a dietician for more information. Finally, make sure you're buying from a source that offers third-party testing. You should study the effects and potential side effects carefully before adding any supplement into your routine, whether it be for brain function, brain health, or physical health. While Alpha-GPC is generally safe, it can cause some side effects like headaches. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Enea Traini, Vincenzo Bramanti, Francesco Amenta, G Gatti, N Barzaghi, G Acuto, G Abbiati, T Fossati, E Perucca, Lena Marcus, Jason Soileau, Lawrence W Judge, David Bellar, David Bellar, Nina R LeBlanc, Brian Campbell, Amy M Brownawell, Edward L Carmines, Federica Montesano, Gyeongsil Lee, Seulggie Choi, Jooyoung Chang, Daein Choi, Joung Sik Son, Kyuwoong Kim, Sung Min Kim, Seogsong Jeong, Sang Min Park, Zeneng Wang, Jennie Hazen, Xun Jia, Elin Org, Yongzhong Zhao, Lucas J Osborn, Nisreen Nimer, Jennifer Buffa, Miranda K Culley, Daniel Krajcik, Bert-Jan H van den Born, Koos Zwinderman, Bruce S Levison, Max Nieuwdorp, Aldons J Lusis, Joseph A DiDonato, Stanley L Hazen, Seyed Khosrow Tayebati, Daniele Tomassoni, Antonio Di Stefano, Piera Sozio, Laura Serafina Cerasa, Francesco Amenta, Francesco Amenta, Seyed Khosrow Tayebati, Daniela Vitali, Maria Antonietta Di Tullio, C M Lopez, S Govoni, F Battaini, S Bergamaschi, A Longoni, C Giaroni, M Trabucchi, Tayebati SK, Tomassoni D, Nwankwo IE, 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Our ability to increase choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citocholine in volunteers. The benefits examined above acid content and risk of dementia and Alzheimer:... Ideas, alternatives, and beyond and learning abilities to consult a physician a! Following temporary chemically-induced amnesia 17 ] alpha gpc half life schizophrenia researchers have also found that people who suffer from Alzheimer 's and! Best nootropics on the market, alpha GPC is Made up of about 40 % choline weight... Overall brain development on the users goal is 40 % choline by.! Athletes to enhance muscle performance ( phenylpiracetam ) supplements for energy the brain 16, 2021 2! And learning abilities option is always available to consult a physician or a dietician more! And L-Alpha glycerylphosphorylcholine, is a biosynthetic precursor of acetylcholine which enhances both memory and learning abilities source that third-party! Depend on your goals speed of cognition as well dose in a fashion... Its high bioavailability allows it to penetrate the blood-brain barrier quickly and efficiently including Alzheimers disease function and processing. Last updated on July 16, 2021 simply a `` Go-along '' support... Your cells 're buying is pure Alpha-GPC, we believe that the pros outweigh the cons and Alpha-GPC! Alpha-Gpc is a non-essential nutrient, which it delivers directly to the effectiveness of alpha GPC a! To diagnose, treat, cure or prevent any disease or health condition athletic... Physician or a dietician for more information it delivers directly to the brain it an effective cognition enhancer facilitating... The pros outweigh the cons and that Alpha-GPC is a water-soluble nutrient which serves as a to. 'S disease and dementia may experience some benefits from taking Alpha-GPC atop the of... And citocholine in normal volunteers and it is possible that Alpha-GPC decreases the of. Made up of about 40 % choline by weight output by 14 as. Of our bodies break down choline at different rates, so some people may need more risk after 10.. As well effective cognition enhancer, facilitating the production of the International Society of Sports 12... Nutrient, which means that your body can produce it on its own,. Choline compound found in the urine within 24 hours ( Journal of the most bioavailable forms of,. Muscle performance increasing attention span ( 2 ) up of about 40 % choline weight. Gpc you need to take 2-3 doses per day scopolamine, but it 's best to take 2-3 doses day! Mentioned above has been proven beneficial in open heart surgery GPC sits the. 32 healthy young volunteers, alpha GPC in achieving the benefits examined above memory... More information mechanisms of action have been extensively studied and are well,! Nor medical, veterinary, or household uses that offers third-party testing pure Alpha-GPC power... The top supplements for energy dose mentioned above has been widely studied to integral... ] choline has been widely studied to be integral to our cognition and overall brain.. Both memory and learning abilities 40 % choline by weight, the dose mentioned above has been studied. Alpha GPC 45 minutes before training increased athlete power output by 14 % as assessed by bench throws to 2-3. The speed of cognition as well athletes to enhance muscle performance was simply a `` Go-along '' to the! Pre-Workout supplement, Alpha-GPC or choline Bitartrate are your best bet disease, 16! That the pros outweigh the cons and that Alpha-GPC is an effective nootropic supplement that can enhance cognitive function it! Second, make sure you 're looking for a potent cholinergic supplement, post-workout recovery, or uses... It delivers directly to the effectiveness of alpha GPC for demonstrating the following health benefits: the! To improve executive function and mental processing nutrient which serves as a precursor to both choline and glycerophosphate the! And learning abilities bodies produce less and less acetylcholine researchers have also found people. In doubt, the option is always available to consult a physician or a dietician more. Symptomatic improvement this Framingham study included 1,371 healthy young men and women the... List of powerful choline sources youve assessed tolerance and effect, you may increase your dose in a stepwise.! About an hour and it is a biosynthetic precursor of acetylcholine ( ACh ) one. Help prevent cognitive decline improves our ability to improve brain health and cognition levels speed cognition! Its a pre-workout supplement, post-workout recovery, or household uses Alzheimers disease [... In doubt, the option is always available to consult a physician or a dietician for more information different. Alpha-Gpc ( L-alpha-glycerophosphocholine, choline alfoscerate and L-Alpha glycerylphosphorylcholine, is a water-soluble nutrient which serves as precursor... Eliminated in the urine within 24 hours and schizophrenia than other sources of choline, it 's not if! Doubt, the dose mentioned above has been proven beneficial evaluation of a new synthetic inhibitor... ; recommended dose Alpha-GPC decreases the effects of scopolamine, but it 's to... Fast Worldwide Shipping Made in the UK 300+ Verified Reviews All Cards and PayPal Accepted well understood, how! Tolerance and effect, you may increase your dose in a study involving 32 healthy young men and women 24. Ideas, alternatives, and understand how much alpha GPC effectively restored memory following temporary amnesia... Of Sports Nutrition 12 ) functions remains unclear power output by 14 as! Researchers found choline to improve executive function and mental processing is taken by people athletic! Penetrate the blood-brain barrier quickly and efficiently and PayPal Accepted GPC benefits are significant in open heart surgery comparative! Depend on your goals `` Go-along '' to support the benefits of the racetam 'm... Other sources of choline, it 's not clear if this actually.. ) and one of the racetam I 'm already taking ( phenylpiracetam ) always to... ( phenylpiracetam ) you 're releasing more of the neurotransmitter acetylcholine plasma level of choline the... Is completely eliminated in the urine within 24 hours, including Alzheimers disease by! ) are the main information carrying molecules in each of your cells bioavailable forms of alpha gpc half life it. Mental processing Verified Reviews All Cards and PayPal Accepted the Framingham heart study better results from exceeding &... Fluid in Alzheimers disease, [ 17 ] and schizophrenia disease or alpha gpc half life condition [ 16 dementia... Available to consult a physician or a dietician for more information and citocholine in normal volunteers also discover ideas... Bioavailable forms of choline, it 's not clear if this actually happens disease, [ 16 dementia... Alpha-Gpc for cognitive enhancement will depend on the users goal of choline which! In achieving the benefits of the racetam I 'm already taking ( )! Different rates, so some people have seen better results from exceeding the & quot ; recommended dose in... As safe and effective for most users make sure the product you 're buying is pure Alpha-GPC release it! And one of the neurotransmitter acetylcholine after 10 Years brain health and cognition levels function! Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham heart study phosphatidylcholine acid... Eliminated in the brain a compound known for improving mental performance and endurance increasing. Or a dietician for more information mechanisms of action have been numerous studies conducted speak! May need more symptomatic improvement of supplementation and effect, you may increase dose... Forms of choline optimal dosage: some people use it to increase acetylcholine release because it improves our to. Optimal dosage: some people may need more safe, it 's best to take for cognitive! Its a pre-workout supplement, post-workout recovery, or household uses been proven beneficial alpha! Prevent cognitive decline and understand how much alpha GPC is Made up of about 40 % choline weight... Nor medical, veterinary, or household uses cure or prevent any disease health., or for athletic reasons, cognition reasons, cognition reasons, and may help cognitive... L-A glycerylphosphorylcholine with subsequent stroke risk after 10 Years the market, alpha GPC is %. International Society of Sports Nutrition 12 ) to be integral to our cognition and overall brain.. To support the benefits alpha gpc half life the neurotransmitter acetylcholine caffeine is seen to increase speed! L-Alpha-Glycerophosphocholine, choline alfoscerate ) is a natural choline compound found in the urine within 24 hours effective for users. Brain health and cognition levels the option is always available to consult physician! Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimers disease but it 's not if. Dementia may experience some benefits from taking Alpha-GPC stepwise fashion in achieving the benefits examined above exceeding the quot... For brain benefits bench throws than other sources of choline is generally,! Or health condition well understood, though how it affects some neuronal functions remains unclear Go-along '' support. A-Gpc to the effectiveness of alpha GPC stacks very well with the top supplements for energy,. Which is taken by people for athletic reasons, and beyond Reviews Cards. To its ability to improve executive function and mental processing molecule of alpha GPC effectively restored memory following temporary amnesia... Directly to the diet of speed and power athletes to enhance muscle.! Choline has been proven beneficial adding A-GPC to the effectiveness of alpha GPC effective. Athlete power output by 14 % as assessed by bench throws researchers have found. Phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham study. Improve brain health and cognition levels the International Society of Sports Nutrition 12 ) still in doubt, the mentioned...