ADVERSE REACTIONS In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. Normal/Normal littermates of dogs with the mutation, if of equal quality, should be given preference for breeding. If your dog ingests a topical product or if you see signs of toxicity after giving oral medication, contact your vet immediately. Teri, this isnt something I know a lot about. For Health. If tests show that your dog is affected by the MDR1 mutation, or if your dog could be affected and has not been tested, make sure that your vet is aware of potential drug sensitivity. If we can choose, we would take a simple medication that provides all-around protection. Mixed-breed dogs from affected breeds or whose parentage is unknown should also be tested, as its impossible to tell for sure just by looking at a dog what its ancestry might be. Thank you. I would probably avoid products that contain spinosad for dogs with the MDR1 mutation. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. One of my girls Rosie started to have a seizure fit on the floor. Ideally, only dogs with no copies of the MDR1 mutation would be used for breeding. https://www.animalgenetics.us/Canine/Genetic_Disease/MDR1.asp, https://todaysveterinarynurse.com/articles/mdr1-genetic-testing-what-you-need-to-know, http://www.ashgi.org/home-page/genetics-info/faq/mdr1-faqs. Luckily, there is Simparica Trio that does exactly that. Bravecto [package insert], Summit, NJ: Merck & Co; 2022. Spinosad, a flea-control medication included in Comfortis, Trifexis, and other products, increases the risk of neurological toxicity even in normal dogs when combined with high doses of ivermectin (and possibly other drugs) used to treat parasites. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Zoetis Inc. Nemex-2 Suspension Approved Package Insert, Kalamazoo, MI: Zoetis Inc; 2019. 488,079 oglasa keyboard_arrow_right Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. The test requires only a simple, non-invasive cheek swab that you can collect yourself and send to WSUs Veterinary Clinical Pharmacology Laboratory (VCPL). Little has been published yet regarding the environmental toxicity of sarolaner. (MDR1 -/-) following single oral administration at 3 times the recommended dose. These drugs are not being recalled or banned, but the FDA has felt the need to alert pet owners to the possibility that the drugs can be potentially troublesome for some pets. High on the list was Simparica Trio. All rights reserved. Simparica has been administered orally to 8 week old Beagle puppies at doses of 0, 1, 3, and 5 times the maximum dose of 4 mg/kg at 28 day intervals for 10 doses. Arthritis: The Number One Cause of Chronic Pain in Your Pet! Hi Vanessa. Thank you Veronique Dunagin, Los Lunas, New Mexico. Hi Becky. Use this in your waiting room or exam room to inform clients. These are likely to be the only common drugs your dog may encounter but we cannot guarantee accuracy as our knowledge is incomplete. We are giving our Aussie puppy revolution for flea/tick prevention but are debating whether we should switch to simparica trio. A Force and Fear Free training community providing support and advice for puppy owners. In a margin of safety study, Simparica was administered orally to 8 week old Beagle puppies at doses of 0, 1, 3, and 5 times the maximum exposure dose of 4 mg/kg at 28 day intervals for 10 doses. Now I am looking for organic ways to keep her healthy Help pleases. This is not reliable, however, as some dogs with white feet may have normal genes, and dogs with non-white feet may be affected by the mutation. LIVE CHAT AVAILABLE productsupport@zoetisus.com. Veronique, I wouldnt hesitate to give your dog with a single copy of the MDR1 mutation heartworm prevention medication at normal doses. Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . All rights reserved. More specifically, NexGard is safe and effective in dogs and puppies 8 weeks of age or older, weighing 4 lbs or more. Collies (including Border Collies, Bearded Collies, and Rough Coated Collies), Shelties, and dogs with pigmented bodies but white feet are prone to a genetic anomaly called the MDR-1 mutation. A: All heartworm products labeled for dogs in the U.S. have been tested in dogs with the MDR1 mutation as required by the FDA and have been found to be safe. If the drug that was used is not listed above, you might also visit our page on seizures and dog flea treatments. Dogs with one copy are less sensitive (able to tolerate a higher dose before adverse effects are seen), but they are more sensitive than normal dogs. As for what is the best, all you need to worry about is making sure that all the drugs you use are not featured in the list above. *as a direct result of killing Ixodes scapularis. It provides 100% protection from heartworm disease. Selamectin caused toxicity at 2.5 times the recommended dose when that amount was given orally, but higher doses are tolerated when the product is applied topically, as directed.Other avermectins can also cause toxicity, including doramectin (Dectomax), eprinomectin (Eprinex), and abamectin. Mar 2013. Resources: http://vcpl.vetmed.wsu.edu/problem-drugs https://www.animalgenetics.us/Canine/Genetic_Disease/MDR1.asp https://todaysveterinarynurse.com/articles/mdr1-genetic-testing-what-you-need-to-know http://www.ashgi.org/home-page/genetics-info/faq/mdr1-faqs. Such dogs are particularly susceptible to treatment with macrocyclic lactones (e.g. The safety studies for NexGard had a good outcome with a very small percentage of dogs experiencing minor adverse effects. Simparica TRIO **NOTE** No returns or refund on Prescription Medication once it has left our Facility. Some additional drugs are known to cause problems for dogs with the MDR1 mutation, while others are suspected to be problematic. The neurological problems tied to Simparica scare the shit out . Kimberly, if your dog did fine with Heartgard, I would return to that. i would chat with your vet about this one honestly. The following list is drugs that are known to be removed from the brain via the MDR1 gene, but appear to be safely tolerated by dogs with the mutation. I use Ivermectic and Strongid to worm horses up to this point. Dogs with the mutation would best be bred to those that are Normal/Normal. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . NexGard [package insert], Duluth, GA: Boehringer Ingelheim; 2019. Hi Andrew, Can I ask have you ever heard of collies with the MDR1 mutation being immune to anaesthetic? is there a best multi treatment for a border collie x. Im currently using NexGard Spectra, dont know if he has the Gene, but Pet barn says I should be using alternative brands. You can use any flea control found on this list that I havent explicitly mentioned in the article above. I would start by getting the puppy tested to be sure that you need to be concerned (unless the mom had a double MDR1 gene, in which case you know your pup is a carrier). Treat and control intestinal parasites to protect dogs. Their status can also be taken into account if any neurological signs appear so that the veterinarian can give a correct diagnosis. I have been since searching for a safe allrounder product, but it is very confusing. Loperamide. Heres what you should know if you are considering this medication for your dog.if(typeof ez_ad_units!='undefined'){ez_ad_units.push([[728,90],'worlddogfinder_com-medrectangle-3','ezslot_2',120,'0','0'])};__ez_fad_position('div-gpt-ad-worlddogfinder_com-medrectangle-3-0'); Simparica Trio can be described as a broad-spectrum parasite preventative that offers protection and treatment to dogs. I give my Australian Shepherd Nexgard for fleas/ticks and Interceptor for heartworms. Simparica TRIO View all products by Zoetis. This is a new extensively tested product now available in Australia that provides optimal protection for your dog. No copies. . Interceptor Plus [package insert]. There weren't as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Some remain safe, others should be avoided. Any dog with the mutation may pass it along to their offspring, but dogs with just one copy of the mutation can also produce normal puppies, particularly when bred to dogs that do not carry the mutation at all. The discoverer of the mutation of the MDR1 gene and establishment of testing procedures, WSU is the sole patent holder for the test to detect the mutant gene. The most important question about any chewable tablet is, Is it safe for my dog? Protection against parasites is essential, but if risks outweigh the benefits, it might be worth looking into other types of protection. The very low doses used for heartworm prevention, however, should not cause any harm, even to dogs with two copies of the defective gene. SIMPARICA TRIO is not effective against adult D. immitis. Im having trouble finding one I can trust. Thank you for your patience. I understand the intention, but this list is incorrect and alarmist. During the end-of-study ophthalmic examination, one 1X dog was found to have . Quick Answer: Is Nexgard Safe For Mdr1 Dogs. Simparica Trio has the same main ingredient as . In 1997, Mary attended a seminar on wolf behavior at. Some had fleas, some had heartworms, and some had roundworms. In addition to ivermectin, the most commonly used problem drugs are acepromazine (Ace), butorphanol (Torbutrol, Torbugesic), and loperamide (Imodium). This safety summary is a complement to the information on product labels and MSDS. Dogs dont seem to dislike the taste; in fact, they seem to love it. In well-controlled laboratory studies. Thank you. If you stick to the main body of the article you will find a very clear list of drugs to avoid. Just one Simparica Trio chewable does the job of two or three parasiticides in a single chewablethe way pet owners prefer to give preventatives to their dogs.3, Approved for puppies as young as 8 weeks old weighing 2.8 lbs or more, Can be given with or without food. Therefore, breeders should consider the mutation a fault like any other and weigh it against the other pros and cons of breeding any particular dog. A few drugs affected by PGP appear to be safe to use in normal doses. Only original prescriptions can be accepted. If your breeder has completed the testing on either the puppy or the parents, please be sure you have a copy of the results to give to your veterinarian so they can be treated appropriately. Hi Shirley. The test will identify whether a dog has one or two copies of the defective gene. WHO Acute Hazard classification of pesticides: Not listed. Zoetis Inc. Study A166-US-17-821. 71 0 obj <> endobj He has been neutered and will not be passing onto other dogs. 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