However, there are concerns that this combination product might cause liver problems in some people. In theory, Baikal skullcap might lower blood pressure too much in people prone to low blood pressure. View abstract. Due to such properties, it is found that this medicine is prominent in dealing with cancer-producing cells. 2000;23(5):272-274. Baikal skullcap might make these pumps less active and increase how much of some medications get absorbed by the body. View abstract. Lin, C. C., Kuo, C. L., Lee, M. H., Lai, K. C., Lin, J. P., Yang, J. S., Yu, C. S., Lu, C. C., Chiang, J. H., Chueh, F. S., and Chung, J. G. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. View abstract. 2008;8(3):264-268. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Zhang CZ, Wang SX, Zhang Y, et al. Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. View abstract. J Ethnopharmacol. View abstract. There have been reports of fever and lung Huang, W. M., Yan, J., and Xu, J. View abstract. Lam, T. L., Lam, M. L., Au, T. K., Ip, D. T., Ng, T. B., Fong, W. P., and Wan, D. C. A comparison of human immunodeficiency virus type-1 protease inhibition activities by the aqueous and methanol extracts of Chinese medicinal herbs. Quality evaluation of commercial extracts of Scutellaria baicalensis. Zhongguo Zhong.Yao Za Zhi 2001;26(11):768-769. View abstract. Life Sci 10-27-2000;67(23):2889-2896. Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of benzo[a]pyrene 7,8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide. Keep in mind that natural products are not always necessarily safe and dosages can be important. Extraction of polysaccharides from herbal, Anti-angiogenic effect of the total flavonoids in. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. The ethyl acetate (EtOAc) extract showed high ROS scavenging ability, and four compounds were subsequently isolated and purified from this extract: baicalin, baicalein, wogonin, and oroxylin A. Baicalein in rat lung mitochondria the most significant LHP-induced LPO inhibition was shown and extracted with EtOAc that contained the Inhibitory effects of flavonoids from Scutellaria baicalensis on Epstein-Barr virus activation and their anti-tumor-promoting activities. View abstract. Seattle, WA: Eastland Press 1996:107-8. Discover the Health Benefits of Mushroom Extracts, Harnessing the Power of Grape Seed Extract for Health Benefits, The Health Benefits of Yohimbe Bark Extract, The Benefits of Leaf Extract: How This Natural Remedy Can Improve Your Health, Understanding Food Grade Tannic Acid: Its Role in Food and Health. Induction of apoptosis by total flavonoids from. 2020 Apr;82(4):253-254. Some medications are changed and broken down by the liver. Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. Ding, X. F., Gao, H. N., Guo, X. H., Wang, Z. Baicalin is believed to interfere with hormonal reactions and release of histamines and bile in the body; it stimulates gallbladder activity, inhibits inflammation, as well as suppresses the activity of leukaemia-derived T-cells and replication of viruses and bacteria. Before taking Baikal skullcap, talk to your healthcare provider if you take any medications that are changed by the liver. ]. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. [Effects of Honeysuckle flower and Scutellaria Baicalensis Georgi on constraction and electric activity of rabbit small intestine smooth muscle]. J Agric Food Chem 4-23-2008;56(8):2838-2845. Guangxi Zhiwu 2008;28(3):373-378. China GMP, NSF cGMP,ISO Certifiate, Halal, Kosher Certificate, Scutellaria Baicalensis: Uses Side Effects And Precautions. Ceska.Slov.Farm. Gao, Z., Huang, K., and Xu, H. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. View abstract. Immunopharmacology 2000;49:295-306. Immunobiology 2006;211(5):359-368. View abstract. View abstract. Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. 2006;5(1):9-29. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. Laboratory studies have shown S. barbata can limit the growth of cancer cells. View abstract. View abstract. Side effects are few and may include drowsiness. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Neuroprotective effects of flavonoids were ameliorated by diazepam, a GABA receptor agonist, suggesting that the components influence GABA receptor activity(5). Chang, W. H., Chen, C. H., and Lu, F. J. Braude MR, Bassily R. Drug-induced liver injury secondary to Scutellaria baicalensis (Chinese skullcap). You may ask and answer a query. Planta Med 1998;64:571-2. Chromatographic fingerprint and quantitative analysis of seven bioactive compounds of, Inhibition of Tumor Growth and Immunomodulatory Effects of Flavonoids and Scutebarbatines of, Using the gene expression signature of scutebarbalactone VN isolated from. The ethyl acetate (EtOAc) extract showed high ROS scavenging ability, and four compounds were subsequently isolated and purified from this extract: baicalin, Mu, R., Qi, Q., Gu, H., Wang, J., Yang, Y., Rong, J., Liu, W., Lu, N., You, Q., and Guo, Q. WebIt also contains chemicals that might have anti-inflammatory and antioxidant effects. Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells. View abstract. Kimura, Y., Yokoi, K., Matsushita, N., and Okuda, H. Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. Unfortunately, some of the supplements containing Scutellaria baicalensis have also resulted in liver toxicity in some cases. J Ethnopharmacol. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use Baikal skullcap. 2005 - 2023 WebMD LLC, an Internet Brands company. Baikal skullcap is also sometimes applied to the skin for psoriasis. Use of this Web site does not create an expressed or implied physician-patient relationship. This will help them manage your care and keep you safe. View abstract. Common substitutions for Baikal skullcap in Chinese medicine include related plants whose scientific names are Scutellaria viscidula, Scutellaria amonea, and Scutellaria ikoninikovii. View abstract. Drugs 2005;65(9):1239-1282. 73.^ Hwang YK, Jinhua M, Choi BR, Cui CA, Jeon WK, Kim H, Kim HY, Han SH, Han JS Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments J Ethnopharmacol. [The Baikal scullcap (Scutellaria baicalensis Georgi)--a potential source of new drugs]. [Application of XRF to the analysis of Scutellaria baicalensis with space mutagenesis]. Biomed.Chromatogr. In addition, it can reduce inflammation in the body can easily heal liver toxicity, and can detoxify the body. 4-12-2011;134(3):884-891. The total content of these 6 main flavonoids account ed for 68.5% of the extract . XI. Zhang H and Huang J. Scutellaria barbata has been studied for its anticancer properties, but more research is needed. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Wang, Z. Yuan Y., Liu Y.J, Luo Y.J, and et al. Burnett BP, Jia Q, Zhao Y, Levy RM. 1999;385-6, 400-1. Che, Q. M., Huang, X. L., Li, Y. M., Kun, Z., Teruaki, A., and Masao, H. [Studies on metabolites of baicalin in human urine]. Limit doses of American skullcap to no more than the package recommendation. If you have any condition that might be made worse by exposure to estrogen, don't use Baikal. Biomed.Chromatogr. View abstract. View abstract. View abstract. Fu, J., Cao, H., Wang, N., Zheng, X., Lu, Y., Liu, X., Yang, D., Li, B., Zheng, J., and Zhou, H. An anti-sepsis monomer, 2',5,6',7-tetrahydroxyflavanonol (THF), identified from Scutellaria baicalensis Georgi neutralizes lipopolysaccharide in vitro and in vivo. Phytother.Res 2009;23(10):1415-1420. 11-12-2009;126(2):320-331. Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. Check your mobile for SMS (Didn't get the message, repeat Step 1). Differential interaction of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. Birth Defects Res B Dev.Reprod.Toxicol. Tong, R., Mehendale, S. R., Wang, C. Z., Shao, Z., and Yuan, C. S. Comparison of antioxidant effects of various Scutellaria baicalensis fractions and the potential role of catalase upregulation. NIH National Cancer Institute. View abstract. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. A traditional Chinese herbal medicine loaded with potent antioxidant and anti-inflammatoryflavonoids such as baicalin, baicalein, and wogonin. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. View abstract. View abstract. 4-26-2011;135(1):179-185. Wei, L., Lu, N., Dai, Q., Rong, J., Chen, Y., Li, Z., You, Q., and Guo, Q. This side effect does not appear to be common and might only occur in people who have a type of allergic reaction to it. Afr J Tradit Complement Altern Med. View abstract. Cancer Lett. Accessed on September 1, 2021. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. WebMD does not provide medical advice, diagnosis or treatment. Cancer Lett. Anticancer Res 2007;27(1A):117-125. 2003;34(3):504-506. Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. View abstract. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Qherb specializes in plant extract and the development of the most effective and specialized botanical ingredients for the pharmaceutical, beverage, health food, and Cosmetic industries. WebBaicalin is a great herbal supplement for health benefits. The active ingredient in Baikal skullcap, baicalin, is used in combination with shung hua (ephedra) to treat upper respiratory tract infections. Skin contact Rinse skin with water/shower. Zhang, K., Guo, Q. L., You, Q. D., Yang, Y., Zhang, H. W., Yang, L., Gu, H. Y., Qi, Q., Tan, Z., and Wang, X. Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. Interactions Do not use Chinese skullcap with alcohol or the following Invest New Drugs 2011;29(4):637-645. Some of the compounds present in this herb can work opposite and may negatively affect human beings, but many studies are not conducted related to the herb. Huang, S. T., Wang, C. Y., Yang, R. C., Chu, C. J., Wu, H. T., and Pang, J. H. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Dosage: 39 g/day/adult. View abstract. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. Puri BK, White N, Monro JA. Liu, S., Ma, Z., Cai, H., Li, Q., Rong, W., and Kawano, M. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. Phytochemistry 2011;72(8):752-760. J Ethnopharmacol 2005;98:295-300. With cancer, where you get treated first matters. Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Chinese Journal of Gerontology 2010;30(7):926-928. View abstract. Baikal skullcap might slow blood clotting. WebSummary: As a traditional Chinese herbal medicine, Scutellaria baicalensis has shown significant effects on the treatment of various diseases, especially hepatitis, diarrhoea, vomiting and high blood pressure. Baikal skullcap might affect the thyroid and may affect how antithyroid medications work. B., and Chun, M. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. Mol Nutr Food Res 2008;52(11):1349-1357. View abstract. 5. Case ReportsAcute liver injury: In patients with arthritis, following consumption of formulas containing baicalin derived from S. baicalensis or Chinese skullcap(18)(24). It is used with other herbs in traditional Chinese medicine to treat bacterial infections, hepatitis, and tumors. S. barbata is an herb found in Korea and southern China. View abstract. Mol Pharmacol 2001;60(3):507-513. Herbal hepatoxicity from Chinese skullcap: A case report. View abstract. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. 2009;30(11):1505-1512. View abstract. vitamins, herbs, dietary supplements a-z list. View abstract. View abstract. Get medical attention if irritation develops and persists. Invest New Drugs 2011;29(4):637-645. View abstract. Bull Exp Biol Med 2004;137(5):471-474. Cell Mol Biol Res 1993;39(2):119-124. Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. Eksp Klin Farmakol 1997;60:28-30. Skullcap should not be used during pregnancy or breastfeeding. Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. Eksp.Klin Farmakol. View abstract. Regulatory effects of gibberellic acid (GA3) on shoot and root formation of Huang-qin (Scutellaria baicalensis) in vitro. J Ethnopharmacol. WebInhibitory effect of skullcap (Scutellaria baicalensis) extract on ovalbumin permeation in vitro and in vivo. Chen C, Mireles RJ, Campbell SD, et al. Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. Baikal skullcap might also lower blood sugar. Biochem Biophys Res Commun 9-24-2000;276(2):534-538. Altavilla D, Squadrito F, Bitto A, et al. View abstract. PC-SPES (PDQ) - Health Professional Version. Yuan Y., Liu Y.J, Luo Y.J, and et al. Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Eur J Haematol. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. View abstract. Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. Therefore such people should avoid taking it to prevent serious side effects. Am J Chin Med 2006;34(2):245-261. View abstract. A traditional Yotsumoto, H., Yanagita, T., Yamamoto, K., Ogawa, Y., Cha, J. Y., and Mori, Y. Inhibitory effects of oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: evidence from the cultured HepG2 cells and in vitro assay of ACAT. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Chalasani N, Vuppalanchi R, Navarro V, et al. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Flavonoids and scutebarbatines can regulate immune function, with decreases in IL-17, IL-10, FOXP3, TGF-beta1, RORgammat, and IL-6 levels, and increases in IL-2 and IFN-gamma levels(23). WebScutellaria Baicalensis Extract. Neurosci Lett. Leung, H. W., Yang, W. H., Lai, M. Y., Lin, C. J., and Lee, H. Z. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. 11-15-2009;171(1-3):508-513. View abstract. View abstract. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. 2019;49(4):544-546. View abstract. View abstract. Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. View abstract. View abstract. Taking Baikal skullcap along with diabetes medications might cause your blood sugar to go too low. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. Nahrung 2004;48(2):123-128. View abstract. In that case, it is either used for hormone synthesis or hormone breakdown, including estrogen and testosterone, which are not advised to combine with the Chinese herb. But there is not enough information to know if Baikal skullcap is the cause of these side effects. Thanks to its salicin content, willow bark is often touted as Chemicals in skullcap might cause sleepiness. Planta Med 2001;67(5):396-399. View abstract. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Taking Baikal skullcap along with diabetes medications might cause blood sugar to drop too low. Intern Med 2001;40:764-8. View abstract. Zhao, M., Zhou, Z. T., and Zhang, W. D. [Antifugal susceptibility testing and antifugal traditional Chinese medicines screening of oral Candida isolated from head and neck cancer patients treated with radiotherapy or chemotherapy]. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Polysaccharides inhibit proliferation and downregulate phospho-c-Met expression and downstream phospho-Erk/Akt signaling(18). View abstract. Food Chem Toxicol. What Are The Several Uses Of This Medicinal Herb? J Biomed.Sci 2011;18:14. With cancer, where you get treated first matters. Baikal skullcap can also affect most peoples blood sugar levels, but people with diabetes can get negative results with the herb. Pursuing basic and translational research across 9 programs and 100+ labs, Focusing on clinical cancer research and population health, Bridging the lab and the clinic through translational research, Fostering interdisciplinary collaborations between laboratory scientists and clinicians, Partnering with other academic and research institutions, Offering state-of-the-art resources for our researchers, Offering a curriculum with a focus on cancer, Connecting college seniors to future careers in biomedicine, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, Integrative Medicine at Home Membership Program, Characterization of chemical constituents in. In lung tumor models, S. barbata inhibits hypoxia-inducible factor-1 alpha and VEGF expression(18). Scutellaria barbata is a perennial herb that is used along with other botanicals in traditional Chinese medicine to treat bacterial infections, hepatitis, and tumors. View abstract. Wu X, Zhang H, Salmani JM, et al. Shang, Y. Lin, Y. L., Dai, Z. K., Lin, R. J., Chu, K. S., Chen, I. J., Wu, J. R., and Wu, B. N. Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery. Kang, T. H., Hong, B. N., Park, C., Kim, S. Y., and Park, R. Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss. Zhou, J., Qu, F., Zhang, H. J., Zhuge, X. H., and Cheng, L. Z. Cancer Sci 2011;102(4):870-876. View abstract. Chan, E., Liu, X. X., Guo, D. J., Kwan, Y. W., Leung, G. P., Lee, S. M., and Chan, S. W. Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats. View abstract. View abstract. Evid Based Complement Alternat Med. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Chamaecyparis Obtusa Leaf Extract: Scutellaria Baicalensis Root Extract: soothing, antioxidant, antimicrobial/ antibacterial, moisturizer/ humectant: goodie: Cinnamomum Cassia Bark Extract: Sodium Hyaluronate: skin-identical ingredient, moisturizer/ humectant Himeji, M., Ohtsuki, T., Fukazawa, H., Tanaka, M., Yazaki, S., Ui, S., Nishio, K., Yamamoto, H., Tasaka, K., and Mimura, A. WebSide Effects Precautions Interactions Dosing Reviews (4) Overview Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. View abstract. 73.^ Hwang YK, Jinhua M, Choi BR, Cui CA, Jeon WK, Kim H, Kim HY, Han SH, Han JS Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion Takeshita K, Saisho Y, Kitamura K, et al. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. Keep in mind that natural products are not always necessarily safe and dosages can be important. Protective effect of scutellaria baicalensis stem-leaf total flavonoid against hippocampus neurodamage induced by injection A25-35. Baikal skullcap might decrease blood sugar. Bacteriostatic activity of combined application of Galla chinensis, Scutellaria baicalensis and Rhizoma coptidis against MRSA in vitro. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc. View abstract. An intravenous preparation that includes Baikal skullcap, forsythia, and honeysuckle has been used under medical supervision with apparent safety in children for up to 7 days. Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. The dose of your diabetes medication might need to be changed. J Nat Prod 2009;72(9):1616-1619. Mol Pharmacol 2001;60(3):507-513. View abstract. 7-28-2004;211(1):39-46. The growing interest in skin lightening has recently renewed attention on the esthetic applications of Chinese herbal medicine. [Analysis of main flavonoids contents of Scutellaria baicalensis]. Efficacy of Scutellaria baicalensis for the treatment of hand, foot, and mouth disease associated with encephalitis in patients infected with EV71: a multicenter, retrospective analysis. Zhongguo Zhong.Yao Za Zhi 2009;34(22):2910-2915. Yoon, S. B., Lee, Y. J., Park, S. K., Kim, H. C., Bae, H., Kim, H. M., Ko, S. G., Choi, H. Y., Oh, M. S., and Park, W. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. T View abstract. [Effects of light on flavonoids accumulation and related gene expression in suspension cultures of Scutellaria baicalensis]. Ann N Y Acad Sci 2007;1095:521-526. Taking Baikal skullcap along with medications that also slow clotting might increase the chances of bruising and bleeding. 1-8-2007;245(1-2):269-274. Lee, S., Kim, D. H., Jung, J. W., Oh, J. H., Park, H. J., Park, C., Huh, Y., Cheong, J. H., Oh, T. H., and Ryu, J. H. Schizandra chinensis and Scutellaria baicalensis counter stress behaviors in mice. View abstract. View abstract. Available at: https://www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq. Pursuing basic and translational research across 9 programs and 100+ labs, Focusing on clinical cancer research and population health, Bridging the lab and the clinic through translational research, Fostering interdisciplinary collaborations between laboratory scientists and clinicians, Partnering with other academic and research institutions, Offering state-of-the-art resources for our researchers, Offering a curriculum with a focus on cancer, Connecting college seniors to future careers in biomedicine, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, Integrative Medicine at Home Membership Program. Am J Chin Med 2008;36(3):517-540. 2020 May;82(5):307-309. Diabetes medications are also used to lower blood sugar. View abstract. Tyrosinase is a key enzyme involved in the synthesis of melanin, the pigment that gives skin color. View abstract. Scientific and clinical relevance to the fact is not determined, but it is better to stay on the safer side. View abstract. baicalensis, also known as Huang Qin or Chinese skullcap, is a root extract used in traditional medicine. View abstract. Planta Med 2001;67(5):396-399. Select a condition to view a list of vitamins. Leuk.Res 2007;31(4):523-530. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. View abstract. Hu, Z., Yang, X., Ho, P. C., Chan, S. Y., Heng, P. W., Chan, E., Duan, W., Koh, H. L., and Zhou, S. Herb-drug interactions: a literature review. Li T.T, Xu H.M, and Liang Z.W. Biol Pharm Bull 2011;34(5):727-733. But there is not enough information to know if Baikal skullcap is the cause of these side effects. Clin Pharmacol Ther 2007;82:726-33. Individual results of the herb on arthritis are not known, but it shows great results when combined with some other supplements. Fan L, Zhang W, Guo D, et al. Planta Med 2000;66(8):694-698. 6-29-2011; View abstract. Ann N Y Acad Sci 2007;1095:521-526. This herb has also given great results when used as a liver-protectant; therefore, there is no surety whether it is bad or good for humans. 11-12-2009;126(2):320-331. In some cases, this might change the effects and side effects of a medication. Analysis of essential oils from different organs of Scutellaria baicalensis. September 2012. 1-27-2011;133(2):634-641. Another Scutellaria Baicalensis Root Extract trade name mixture (90% ethanol and butylene glycol extract) Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. Kimura, Y., Matsushita, N., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. Morgan SL, Baggott JE, Morel, L, Desmond R, and Kendrach AC. Toxicology 5-2-2009;259(1-2):10-17. International Journal of Pharmacology 2010;6(2):81-88. Yeh J.H, Chiu H.F, Wang J.S., and et al. New York, NY: CRC Press LLC. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Bleeding disorders. View abstract. 2008;57(3):111-114. B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? View abstract. View abstract. 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