Astaxanthin is also responsible for the iconic reddish-orange color of marine animals like salmon and shrimp2, who receive the phytonutrient from the algae they consume. View abstract. Note that the numbers in parentheses (1, 2, etc.) In case you missed it above, astaxanthin is a powerful antioxidant. J.Atheroscler.Thromb. Side effects of astaxanthin may include increased.Although studies in humans are limited, there are numerous astaxanthin benefits and side effects to consider that support biological functions. 2008;9:17. Bolin, A. P., Macedo, R. C., Marin, D. P., Barros, M. P., and Otton, R. Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. If you are taking prescribed medication always talk to your healthcare provider before starting a new supplement. View abstract. Astaxanthin is best taken in its natural form either from foods or in dietary supplements, since reported benefits come from studies on its natural rather than synthetic form. View abstract. Astaxanthin might change how quickly the liver breaks down these medications. View abstract. 2008;46(3):283-290. The greatest attribute of astaxanthin is that it's both a powerful antioxidant and anti-inflammatory. Astaxanthin supplementation does not augment fat use or improve endurance performance. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. J Nutr Biochem 2010;21(5):381-389. It's unclear what effect this may have, but prescription medicines that affect the same enzyme may cause side effects, such as: One small study showed astaxanthin combined with saw palmetto actually increased testosterone, which could help libido. Chen JT, Kotani K. Astaxanthin as a potential protector of liver function: a review. Astaxanthin is also found in several types of seafood, including: Four ounces of sockeye salmon contains about 4.5 milligrams of astaxanthin. View abstract. A comparison of the Anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Limited human evidence suggests that it has some positive effects on oxidative stress, but it's unclear if it's particularly effective for any health outcomes. View abstract. Brain Res 2-13-2009;1254:18-27. Astaxanthin is a powerful carotenoid with antioxidant properties, which is a natural compound that can reduce oxidative stress in the body caused by free radicals. 2012;52(4):382-392. 2009 - 2023 MindBodyGreen LLC. Biochem.Biophys.Res.Commun. And get this: Astaxanthin is estimated to be 6,000 and 100 times stronger than vitamins C and E, respectively. Am J Cardiol 5-22-2008;101(10A):20D-29D. In terms of other side effects, some reported effects of taking oral zinc include indigestion, diarrhea and headaches. Astaxanthin is a type of carotenoid, which is a natural pigment found in a variety of foods. With astaxanthin to help support skin hydration, elasticity, and smoothness. And it may stimulate the immune system. Chew BP, Park JS, Wong MW, et al. BPA is a common chemical found in hard plastics that can disrupt female hormone production. Astaxanthin is a potent antioxidant, with studies showing it provides significantly greater antioxidant protection than the carotenoids beta carotene, lycopene, and lutein as well as alpha-tocopherol, and thus it is considered one of the best agents for protecting cellular membranes. Some laboratory studies have shown astaxanthin may hinder an enzyme called 5-alpha-reductase. Of course, you have to weight this with all the chemical toxins in fish. Eye problems like macular degeneration and cataracts are common concerns associated with aging. Cardounel, A. J., Dumitrescu, C., Zweier, J. L., and Lockwood, S. F. Direct superoxide anion scavenging by a disodium disuccinate astaxanthin derivative: Relative efficacy of individual stereoisomers versus the statistical mixture of stereoisomers by electron paramagnetic resonance imaging. View abstract. As we review the topic of astaxanthin side effects, we will focus on both the positive and any potential negative side effects. * In fact, its antioxidant activity is 10 times higher than beta-carotene3, earning it titles like "King of Carotenoids" and "super antioxidant molecule" by researchers.*. The other protects the water-soluble part of cells. This is because it can protect cells from oxidative stress (are you seeing a pattern here?). BMC.Nephrol. Thanks to its increasing popularity, you can easily find astaxanthin supplements at most pharmacies and health food stores. Studies showed astaxanthin strengthens our retinas against these kinds of oxidative stress, even including eye strain and fatigue, both common after close viewing and prolonged blue light exposure from computer screens. Br J Nutr 2007;98(1):38-44. 2008;107(6):1730-1740. J Am Coll Nutr. B., Xu, Y. X., Zhao, H., Zhu, Q. Y., and Zhu, C. Q. Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial. In addition to astaxanthin, other important eye vitamins include lutein, zinc, vitamin A and zeaxanthin. View abstract. Jyonouchi H, Sun S, Tomita Y, et al. Astaxanthin is no exception a randomized, controlled trial published in 2012, involving 96 subjects, reported a significant improvement in cognition after being supplemented with the antioxidant for 12 weeks. An animal? Learn more about its usage, effectiveness and benefits. View abstract. What are the risks of taking astaxanthin? Adding it into your diet or incorporating a natural supplement can be a powerful way to improve several aspects of health thanks to the axtaxanthin benefits this antioxidant provides. View abstract. Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin, and canthaxanthin. Nutr Cancer 2000;36:59-65. A review of astaxanthin suggests that it may have a negative impact on adaptations to exercise. Information from this source is evidence-based and objective, and without commercial influence. View abstract. We will cover the specifics on choosing the right dose of astaxanthin a little later. This should not be a concern, though. Therefore, its a good idea to only take astaxanthin (or any antioxidant supplement) at the recommended dose to prevent any potential impacts on exercise performance. Therefore, its best to choose a natural form of astaxanthin! Astaxanthin (3,3'-dihydroxy-,'-carotene-4,4'-dione) is a nonprovitamin A carotenoid classified as a xanthophyll and is found in high amounts in the red pigment of crustacean shells (e.g., crabs, shrimp), salmon, trout, and asteroides. Not only is wild salmon naturally higher in this important carotenoid, but its also been shown to be safer for consumption and contain fewer contaminants. Astaxanthin is the pigment that gives seafood like lobster, shrimp and crab that characteristic red hue. Astaxanthin is a carotenoid, like beta-carotene. In addition, astaxanthin protects against UV-induced skin deterioration and helps maintain healthy skin in healthy people, according to a randomized, double-blind, placebo-controlled trial in healthy study participants. As one of the most potent carotenoids and antioxidants found in nature, astaxanthin benefits many aspects of health, from diminishing wrinkles to upgrading your workout routine. Side effects. Nishigaki, I., Rajendran, P., Venugopal, R., Ekambaram, G., Sakthisekaran, D., and Nishigaki, Y. Cytoprotective role of astaxanthin against glycated protein/iron chelate-induced toxicity in human umbilical vein endothelial cells. Medicament for improvement of duration of muscle function or treatment of muscle disorders or diseases. However, when taken in large dosages, potential side effects report changes in sex drive, increased skin pigmentation, hair growth, decreased blood pressure, altered hormone levels and . Fun times. A. View abstract. Additionally, men treated with astaxanthin achieved higher rates of pregnancy compared with a placebo group. Remember the free radicals we discussed above that can damage cells? Its actually none of the above! View abstract. Nutrients 2021;13(9):2917. These health benefits of astaxanthin span multiple areas of wellness, below:*, As it turns out, biotin and collagen aren't the only superstar skin supplements. *, Carotenoids in general are associated with heart health, and astaxanthin is no exception. According to a review out of Australia, there have been at least eight clinical studies measuring the effects of astaxanthin that have shown that astaxanthin supplementation may lower markers of both inflammation and oxidative stress. The effects of astaxanthin supplementation on obesity, blood pressure, CRP, glycemic biomarkers, and lipid profile: A meta-analysis of randomized controlled trials. Am J Ther 2010;17(2):125-132. Eur J Nutr. View abstract. S-adenosyl-L-methionine (SAMe) is a compound found naturally in the body. Astaxanthin is a carotenoid and very high intakes of carotenoids can cause your skin to turn orange. Spirulina aids in the removal of toxins from the body since it is a natural cleanser. * A pair of clinical studies7 also found that astaxanthin can improve the appearance of age spots, wrinkles, and skin elasticity in both men and women. It is related to beta- carotene and vitamin A. In men and those with penises, progesterone plays a role in sperm and testosterone production. highest oxygen radical absorbance capacity. Asian J Androl 2005;7:257-62.. View abstract. The Effect of Astaxanthin on Oxidative Stress Indices in Patients With Polycystic Ovary Syndrome. Research finds that spirulina also boosts the production of . In particular, this beneficial pigment lends its vibrant red-orange color to foods like krill, algae,salmonand lobster. Unlike drug manufacturers, the makers of supplements dont have to show their products are safe or effective before selling them on the market. Antioxidant activities of astaxanthin and related carotenoids. Cell Biol Toxicol. Keywords: astaxanthin, obese dogs, lipid metabolism, anti-oxidative activity, liver function. Yuan, J. P., Peng, J., Yin, K., and Wang, J. H. Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Over time, astaxanthin can cause a variety of positive "side effects." A single-blind clinical investigation. In vitro effects of astaxanthin combined with ginkgolide B on T lymphocyte activation in peripheral blood mononuclear cells from asthmatic subjects. J Clin Med Res 2016;8(10):701-4. The kidneys filter your blood and remove wastes. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Since it can act as a powerful antioxidant, it could have a protective effect on the kidneys. Front Nutr 2022;8:796951. Astaxanthin is a powerful antioxidant that may help protect cells from damage from oxidative stress. Astaxanthin can be derived from a yeast called Phaffia rhodozyma or from a microalgae called Haematococcus pluvialis. It is also available through many online retailers if you have trouble finding it in your area. are clickable links to medically peer-reviewed studies. Int J Environ Res Public Health 2022;19(20):13492. Research suggests that astaxanthin may support healthy blood pressure levels already within normal range. Earnest CP, Lupo M, White KM, Church TS. O'Connor I, O'Brien N. Modulation of UVA light-induced oxidative stress by beta-carotene, lutein and astaxanthin in cultured fibroblasts. are clickable links to these studies. Eur J Pharm Biopharm. A., Glamm, J. E., and Failla, M. L. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. * And a 2020 study found that due to its antioxidant properties, astaxanthin may support overall cardiovascular health . However, the strongest results have been observed at 6 milligrams a day6. However, more research is needed before astaxanthin can be recommended for any of these uses. *, As astaxanthin supports the heart, it may also benefit the brain. Of course, a healthy diet containing astaxanthin is just one piece of the puzzle. View abstract. View abstract. Cell and animal studies show promising results and we look forward to more research into this exciting area of health! She has a Master of Science in Nutrition from Texas Woman's University and Bachelor of Science in Dietetics from SUNY Oneonta. Fletcher, A. E., Bentham, G. C., Agnew, M., Young, I. S., Augood, C., Chakravarthy, U., de Jong, P. T., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J. R., and Vioque, J. Sunlight exposure, antioxidants, and age-related macular degeneration. Mark L Anderson 1 Best of all, its easy to incorporate in your diet and can be easily found in a wide range of nutritious whole food sources. Lee, D. H., Kim, C. S., and Lee, Y. J. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. [1], [2], [3] Natural astaxanthin has been shown to be 20 . Astaxanthin might also improve the way the immune system functions. Briviba, K., Bornemann, R., and Lemmer, U. Visualization of astaxanthin localization in HT29 human colon adenocarcinoma cells by combined confocal resonance Raman and fluorescence microspectroscopy. Researchers note that synthetic astaxanthin is chemically different from synthetic astaxanthin. Astaxanthin is a carotenoid that is mostly found in marine sources. Sekikawa T, Kizawa Y, Li Y, Takara T. Cognitive function improvement with astaxanthin and tocotrienol intake: a randomized, double-blind, placebo-controlled study. It's unclear what effect this may have, but prescription medicines that affect the same enzyme may cause side effects, such as: Brown DR, Warner AR, Deb SK, Gough LA, Sparks SA, McNaughton LR. Fassett, R. G. and Coombes, J. S. Astaxanthin: a potential therapeutic agent in cardiovascular disease. Astaxanthin biochemical properties website. View abstract. Bloomer RJ, Fry A, Schilling B, Chiu L, et al. Nakanishi R, Kanazashi M, Tanaka M, Tanaka M, Fujino H. Impacts of astaxanthin supplementation on walking capacity by reducing oxidative stress in nursing home residents. Potential side effects that may occur with supplementation include hormone changes, increased skin pigmentation, hair growth and altered levels of calcium. Natural Standard Professional Monograph: "Astaxanthin.". J.Dermatol.Sci. In fact, astaxanthin may help support the health of these body systems. Some men take saw palmetto so their body's level of dihydrotestosterone decreases and the level of testosterone increases. Effect of antioxidants on the immune response of Helicobacter pylori. Arch.Toxicol. View abstract. It might, sure. Bioorg.Med Chem Lett 8-2-2004;14(15):3985-3991. Mood, Cramps, and More. People use astaxanthin for many purposes,. Plasma appearance of unesterified astaxanthin geometrical E/Z and optical R/S isomers in men given single doses of a mixture of optical 3 and 3'R/S isomers of astaxanthin fatty acyl diesters. A cell study found that astaxanthin was protective to reproductive cells. After all, reducing oxidative stress allows many parts of the body to function more efficiently. View abstract. Health Conditions Featured Breast Cancer IBD Migraine Multiple Sclerosis (MS) Rheumatoid Arthritis Type 2 Diabetes Sponsored Topics Articles. Nutrients. View abstract. 2020;67(3):307-316. At this point, you may be wondering: How much astaxanthin should I take?. Once inside a cell, astaxanthin can lend its electrons to stabilize free radicals. Lockwood, S. F., Jackson, H. L., and Gross, G. J. Retrometabolic syntheses of astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) conjugates: a novel approach to oral and parenteral cardio-protection. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin. Note that the numbers in parentheses (1, 2, etc.) (Accessed 5 June 2002). Astaxanthin is an antioxidant with a range of health benefits, including female hormone balance. What are the side effects of Astaxanthin? Zhou X, Cao Q, Orfila C, Zhao J, Zhang L. Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing. 2007;37(6):519-532. View abstract. Side Effects and Toxicity Because astaxanthi influences hormonal changes one should be aware that it might negatively interact with some hormone-altering medications. Nir, Y., Spiller, G., and Multz, C. Effect of an astaxanthin containing product on rheumatoid arthritis. Comp Biochem Physiol C.Toxicol Pharmacol 2004;139(1-3):99-110. Z Angew Chem 1938; 51: 465-466. Specifically, it's a type of carotenoid1, or a natural pigment that gives foods like pumpkin and carrots their red-orange-yellow hue. While there are many potential causes of heart disease, oxidative stress and inflammation are believed to be front and center more often than not. 2011;66:363-369. While astaxanthin has grown in popularity over the years, the name may still be new to you. View abstract. Since antioxidants are protective against stress from exercise, antioxidants could prevent the body from adapting to exercise. URL: https://www.astaxanthin.org. J Neurochem. Takemoto M, Yamaga M, Furuichi Y, Yokote K. Astaxanthin improves non-alcoholic fatty liver disease in Werner Syndrome with diabetes mellitus. Carcinogenesis 1994;15:15-9. Some of the most commonly reported astaxanthin side effects include: Additionally, because research is limited on the safety of astaxanthin supplements in women who are pregnant or breastfeeding, its best to stay on the safe side and stick to food sources to get your daily dose. Here are 5 promising benefits and uses of saw palmetto. Most of the small research studies to date have used between 2 mg and 12mg daily. An animal study found astaxanthin to be beneficial for the healthy aging of ovaries, an important piece of the reproductive system. Using astaxanthin as a dietary supplement may have certain beneficial side effects, according to research. Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trial. Our online classes and training programs allow you to learn from experts from anywhere in the world. Studies show that it may have multiple beneficial effects when it comes to upping exercise performance and preventing injury. Astaxanthin may interact with 5-alpha-reductase inhibitors, calcium salts, diabetes drugs, drugs that affect bleeding, heart medications, hormonal agents, immunosuppressants, and rofecoxib. However, further research in humans is needed to understand how astaxanthin may affect inflammation and disease in humans. We know that carotenoids are antioxidants and may have certain health benefits. J Am Coll Nutr. Manabe, E., Handa, O., Naito, Y., Mizushima, K., Akagiri, S., Adachi, S., Takagi, T., Kokura, S., Maoka, T., and Yoshikawa, T. Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. View abstract. *) After all, it's not a competition. Folia Histochem.Cytobiol. View abstract. [12] reported that intestinal absorption of astaxanthin is adequate. Panminerva Med 2010;52:49-54. Methods Find Exp Clin Pharmacol 2001;23:79-84. 2021;24(1):92-97. Ito N, Seki S, Ueda F. The protective role of astaxanthin for UV-induced skin deterioration in healthy people-A randomized, double-blind, placebo-controlled trial. Iwamoto, T., Hosoda, K., Hirano, R., Kurata, H., Matsumoto, A., Miki, W., Kamiyama, M., Itakura, H., Yamamoto, S., and Kondo, K. Inhibition of low-density lipoprotein oxidation by astaxanthin. The only problem? J Agric Food Chem 6-28-2006;54(13):4593-4599. Anticancer Res 1999;19:1849-54. Find out the best astaxanthin foods, supplement recommendations, side effects and more. View abstract. J Photochem.Photobiol.B 12-1-2006;85(3):205-215. View abstract. Farmed salmon, on the other hand, are lacking in this important carotenoid as they follow a diet composed primarily of fish meal and oils, giving them a grayish hue. MF Afragil(R) in the treatment of 34 menopause symptoms: a pilot study. Is astaxanthin good for inflammation? 3. Popular brands of naturally derived astaxanthin include BioAstin and Puritans Pride. SAMe helps produce and regulate hormones and maintain cell membranes. OTHER NAME(S): Astaxanthine, Astaxantina, Dihydroxy-3,3 dioxo-4, Astaxanthin has most often been used by adults in doses of 4-18 mg by, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, The Role Gut Bacteria Plays on the Overall Body. The amount of astaxanthin found in whole food sources is generally safe and can be consumed with minimal risk of side effects. When it comes to antioxidant supplements, nutrients like vitamin C and vitamin E often steal the show. A small study conducted at Ghent University Hospital actually found that astaxanthin improved the movement of sperm cells and enhanced the ability of sperm to fertilize eggs. Cicero, AF, Rovati LC, and Setnikar I. Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. Primarily found in seafood, there are a variety of ways for you to get in plenty of this beneficial antioxidant. View abstract. As a result, it could keep testosterone from changing into the hormone DHT in the body. Since the research on astaxanthin is continuing to grow, its best for those who are pregnant or nursing to avoid taking it as a dietary supplement at this time. Conclusion: ASX supplementation (0.3 mg/kg body weight/day) for 6 weeks in healthy dogs and 8 weeks in obese dogs induced the elevation of antioxidant function and of liver function by ameliorating lipid metabolism. Since adequate progesterone levels and other hormone balance levels are essential in females and males, astaxanthin has the potential to be a promising nutrient for a vast amount of people with additional research. Czeczuga-Semeniuk, E. and Wolczynski, S. Dietary carotenoids in normal and pathological tissues of corpus uteri. View abstract. It might be useful as a treatment for problems that involve inflammation, such as: Laboratory research has found that an extract from algae that makes astaxanthin slowed the growth of breast and skin cancer cells. Consider astaxanthin (asta-ZAN-thin), an antioxidant that's gaining popularity in the world of wellness. Nir, Y., Spiller, G., and Multz, C. Effect of an astaxanthin containing product on carpal tunnel syndrome. In the same study, the administration of astaxanthin enabled the cells to mature normally and produce more estrogen and progesterone. Guerin, M., Huntley, M. E., and Olaizola, M. Haematococcus astaxanthin: applications for human health and nutrition. Astaxanthin is a reddish pigment that belongs to a group of chemicals called carotenoids. There has been a lot of study on how astaxanthin can affect endurance, as well as fatigue levels after exercise. Nutr Res 2022;99:40-50. View abstract. Progesterone is a hormone found in all people that can play a role in increasing appetite and metabolism. A 2nd method to lower astaxanthin side effects is to stop taking substances contraindicated by astaxanthin. As a result, it could keep testosterone from changing into the hormone DHT in the body.Read user ratings and reviews for ASTAXANTHIN on WebMD . View abstract. 1999;Patent Cooperation Treaty application #9911251, Lignell, . WebMD does not provide medical advice, diagnosis or treatment. J Clin Biochem Nutr. View abstract. Learn how to use astaxanthin to support your health goals. * That's because the brain relies on a constant supply of blood and oxygen from the heart9. Urakaze M, Kobashi C, Satou Y, et al. View abstract. It may be helpful in preventing plaque buildup in arteries in the heart. What Vitamins and Supplements Can Help you Address a Hormonal Imbalance? J Nutr 1995;125:2483-92. 2000;48:1150-4.. View abstract. Canthaxanthin and astaxanthin is no exception, you have trouble finding it in your.. Aware that it might negatively interact with some hormone-altering medications red hue may helpful. Of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin may hinder an enzyme called 5-alpha-reductase with B! In vitro effects of taking oral zinc include indigestion, diarrhea and headaches nir, Y., Spiller G.! Infertility: a pilot study ( MS ) Rheumatoid Arthritis type 2 Diabetes Topics! 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